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Issue 13, 2006
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Carboxamide–pyridine N-oxide heterosynthon for crystal engineering and pharmaceutical cocrystals

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Abstract

The novel carboxamidepyridine N-oxide synthon, sustained via N–H⋯O hydrogen bonding and C–H⋯O interaction, is shown to assemble isonicotinamide N-oxide in a triple helix architecture and the same heterosynthon is exploited to synthesize cocrystals of barbiturate drugs with 4,4′-bipyridine N,N′-dioxide.

Graphical abstract: Carboxamide–pyridine N-oxide heterosynthon for crystal engineering and pharmaceutical cocrystals

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Supplementary files

Article information


Submitted
01 Nov 2005
Accepted
29 Dec 2005
First published
25 Jan 2006

Chem. Commun., 2006, 1369-1371
Article type
Communication

Carboxamidepyridine N-oxide heterosynthon for crystal engineering and pharmaceutical cocrystals

L. S. Reddy, N. J. Babu and A. Nangia, Chem. Commun., 2006, 1369
DOI: 10.1039/B515510J

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