Issue 13, 2006

Carboxamide–pyridine N-oxide heterosynthon for crystal engineering and pharmaceutical cocrystals

Abstract

The novel carboxamidepyridine N-oxide synthon, sustained via N–H⋯O hydrogen bonding and C–H⋯O interaction, is shown to assemble isonicotinamide N-oxide in a triple helix architecture and the same heterosynthon is exploited to synthesize cocrystals of barbiturate drugs with 4,4′-bipyridine N,N′-dioxide.

Graphical abstract: Carboxamide–pyridine N-oxide heterosynthon for crystal engineering and pharmaceutical cocrystals

Supplementary files

Article information

Article type
Communication
Submitted
01 Nov 2005
Accepted
29 Dec 2005
First published
25 Jan 2006

Chem. Commun., 2006, 1369-1371

Carboxamidepyridine N-oxide heterosynthon for crystal engineering and pharmaceutical cocrystals

L. S. Reddy, N. J. Babu and A. Nangia, Chem. Commun., 2006, 1369 DOI: 10.1039/B515510J

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