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Issue 8, 2006
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The ying and yang of asymmetric aminocatalysis

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During the last six years the asymmetric catalysis of carbonyl transformations via iminium ion and enamine intermediates using chiral amines as organocatalysts has grown most remarkably. In this personal account an overview of this area is given. The field can be divided into two sub areas: (a) Iminium catalysis, which is typically used for cycloadditions and conjugate additions to enals and enones and (b) Enamine catalysis, which is commonly used in electrophilic α-substitution reactions of ketones and aldehydes. A common origin of the two catalysis principles is proposed and their recent merger in tandem sequences is discussed.

Graphical abstract: The ying and yang of asymmetric aminocatalysis

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Publication details

The article was first published on 20 Jan 2006

Article type: 40th Anniversary Article
DOI: 10.1039/B514296M
Citation: Chem. Commun., 2006,0, 819-824

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    The ying and yang of asymmetric aminocatalysis

    B. List, Chem. Commun., 2006, 0, 819
    DOI: 10.1039/B514296M

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