Issue 48, 2006
From the journal:

Chemical Communications

Exploring cocrystal–cocrystal reactivity vialiquid-assisted grinding: the assembling of racemic and dismantling of enantiomeric cocrystals†

Tomislav Friščić,a   László Fábián,b   Jonathan C. Burley,c   William Jones*a  and  W. D. Samuel Motherwellb  

* Corresponding authors

a Pfizer Institute for Pharmaceutical Materials Science, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: wj10@cam.ac.uk

b Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge, UK

c Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK

Abstract

The reaction between pairs of enantiomeric cocrystals involving caffeine or theophylline and a chiral cocrystal former has been investigated by liquid-assisted grinding: we demonstrate two different outcomes for such cocrystal–cocrystal reactions.

Graphical abstract: Exploring cocrystal–cocrystal reactivity via liquid-assisted grinding: the assembling of racemic and dismantling of enantiomeric cocrystals

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Article information

DOI
https://doi.org/10.1039/B613073A
Article type
Communication
Submitted
11 Sep 2006
Accepted
26 Oct 2006
First published
09 Nov 2006

Chem. Commun., 2006, 5009-5011

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Exploring cocrystal–cocrystal reactivity via liquid-assisted grinding: the assembling of racemic and dismantling of enantiomeric cocrystals

T. Friščić, L. Fábián, J. C. Burley, W. Jones and W. D. S. Motherwell, Chem. Commun., 2006, 5009 DOI: 10.1039/B613073A

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