Issue 27, 2006

Total synthesis of the macrocyclic cysteine knot microprotein MCoTI-II

Abstract

The first total synthesis of MCoTI-II, a cysteine knot microprotein and potent trypsin inhibitor, is described; a synthetic strategy has been developed that combines efficient backbone construction via optimised solid phase peptide synthesis with one-pot ‘thia-zip’ native chemical ligation and refolding to yield the natural product.

Graphical abstract: Total synthesis of the macrocyclic cysteine knot microprotein MCoTI-II

Supplementary files

Article information

Article type
Communication
Submitted
23 May 2006
Accepted
01 Jun 2006
First published
20 Jun 2006

Chem. Commun., 2006, 2848-2850

Total synthesis of the macrocyclic cysteine knot microprotein MCoTI-II

P. Thongyoo, E. W. Tate and R. J. Leatherbarrow, Chem. Commun., 2006, 2848 DOI: 10.1039/B607324G

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