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Issue 30, 2006
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Synthesis of the ester side chains of some potently antileukemic harringtonia alkaloids from chiral citrates

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Abstract

The selective reduction of one of the three carboxyl groups of two chiral citric acid derivatives to the corresponding aldehydes, under Rosenmund conditions, are reported together with the application of these aldehydes to the syntheses of the ester side chains of some potently antileukemic Cephalotaxus alkaloids e.g. anhydroharringtonine.

Graphical abstract: Synthesis of the ester side chains of some potently antileukemic harringtonia alkaloids from chiral citrates

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Article information


Submitted
13 Apr 2006
Accepted
02 Jun 2006
First published
26 Jun 2006

Chem. Commun., 2006, 3243-3245
Article type
Communication

Synthesis of the ester side chains of some potently antileukemic harringtonia alkaloids from chiral citrates

R. A. Ancliff, A. T. Russell and A. J. Sanderson, Chem. Commun., 2006, 3243
DOI: 10.1039/B605339D

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