Issue 29, 2006
From the journal:

Chemical Communications

Microarrays of heparinoligosaccharides obtained by nitrous acid depolymerization of isolated heparin†

Jose L. de Paz,a   Dorothe Spillmannb  and  Peter H. Seeberger*a  

* Corresponding authors

a Laboratory for Organic Chemistry, Swiss Federal Institute of Technology (ETH) Zürich, Wolfgang-Pauli-Str. 10, HCI F315, Zürich, Switzerland
E-mail: seeberger@org.chem.ethz.ch
Fax: +41 44 6331235
Tel: +41 44 6332103

b Department of Medical Biochemistry and Microbiology, Uppsala University, P. O. Box 582, Sweden

Abstract

Heparin oligosaccharides derived by nitrous acid depolymerization of heparin have been immobilized on amine-coated glass slides. The formation of a Schiff base creates heparin chips that are a suitable platform for the high-throughput analysis of carbohydrate–protein interactions.

Graphical abstract: Microarrays of heparin oligosaccharides obtained by nitrous acid depolymerization of isolated heparin

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Article information

DOI
https://doi.org/10.1039/B605318A
Article type
Communication
Submitted
12 Apr 2006
Accepted
01 Jun 2006
First published
14 Jun 2006

Chem. Commun., 2006, 3116-3118

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Microarrays of heparin oligosaccharides obtained by nitrous acid depolymerization of isolated heparin

J. L. de Paz, D. Spillmann and P. H. Seeberger, Chem. Commun., 2006, 3116 DOI: 10.1039/B605318A

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