Issue 22, 2006
From the journal:

Chemical Communications

PAMAM dendrimers for efficient siRNA delivery and potent gene silencing†

Jiehua Zhou,a   Jiangyu Wu,ab   Nadia Hafdi,c   Jean-Paul Behr,d   Patrick Erbacherc  and  Ling Peng*ab  

* Corresponding authors

a College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, China

b Département de Chimie, CNRS UMR 6114, 163 avenue de Luminy, France
E-mail: ling.peng@univmed.fr
Fax: 00 33 4 91 82 93 01
Tel: 00 33 4 91 82 91 54

c Polyplus-transfection SA, Bioparc, Boulevard S. Brandt, BP90018, France
E-mail: perbacher@polyplus-transfection.com

d Laboratoire de Chimie Génétique, Faculté de Pharmacie, CNRS UMR7514, France

Abstract

Genuine, nondegraded PAMAM dendrimers self-assemble with siRNA into nanoscale particles that are efficient for siRNA delivery and induce potent endogenous gene silencing.

Graphical abstract: PAMAM dendrimers for efficient siRNA delivery and potent gene silencing

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Article information

DOI
https://doi.org/10.1039/B601381C
Article type
Communication
Submitted
30 Jan 2006
Accepted
03 May 2006
First published
10 May 2006

Chem. Commun., 2006, 2362-2364

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PAMAM dendrimers for efficient siRNA delivery and potent gene silencing

J. Zhou, J. Wu, N. Hafdi, J. Behr, P. Erbacher and L. Peng, Chem. Commun., 2006, 2362 DOI: 10.1039/B601381C

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