Probing the microenvironments in the grooves of Z-DNA using dan-modified oligonucleotides

Takumi Kimura; Kiyohiko Kawai; Tetsuro Majima

doi:10.1039/B600026F

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Probing the microenvironments in the grooves of Z-DNA using dan-modified oligonucleotides†

Takumi Kimura,^a Kiyohiko Kawai^a and Tetsuro Majima*^a

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* Corresponding authors

^a The Institute of Scientific and Industrial Research (SANKEN), Osaka University Mihogaoka 8-1, Ibaraki, Japan
E-mail: majima@sanken.osaka-u.ac.jp
Fax: (+81)6-6879-8499
Tel: (+81)6-6879-8495

Abstract

The environment-sensitive fluorophore dan (6-dimethylamino-2-acyl-naphthalene)- modified dC or dG bases were introduced into the Z-DNA forming sequence. It was demonstrated that both grooves of Z-DNA are more hydrated than those of B-DNA. Dan will be useful for probing the microenvironments in the grooves among the DNA polymorphs.

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Supplementary files

UV titration of the Z-DNA forming sequence ( ODN 1). The excitation spectra of ODNs 2 and 3 were monitored at 460 nm. The CD spectra of ODNs 2-4 in the presence of NaCl PDF (116K)

Article information

DOI: https://doi.org/10.1039/B600026F
Article type: Communication
Submitted: 03 Jan 2006
Accepted: 14 Feb 2006
First published: 28 Feb 2006

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Chem. Commun., 2006, 1542-1544

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Probing the microenvironments in the grooves of Z-DNA using dan-modified oligonucleotides

T. Kimura, K. Kawai and T. Majima, Chem. Commun., 2006, 1542 DOI: 10.1039/B600026F

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Chemical Communications

Probing the microenvironments in the grooves of Z-DNA using dan-modified oligonucleotides†

Abstract

Supplementary files

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Probing the microenvironments in the grooves of Z-DNA using dan-modified oligonucleotides

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