A lag-phase in the reduction of flavin dependent thymidylate synthase (FDTS) revealed a mechanistic missing link†
Abstract
An unexpected substrate-dependent lag-phase, found in the single turnover
* Corresponding authors
a
Department of Chemistry, The University of Iowa, Iowa City, IA, USA
E-mail:
amnon-kohen@uiowa.edu
Fax: 01-319-335-1270
Tel: 01-319-335-0234
b
Department of Biochemistry, The University of Iowa, Iowa City, IA, USA
E-mail:
todd-washington@uiowa.edu
Fax: 01-319-335-9570
Tel: 01-319-335-7518
c
The Genomics Institute of Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, USA
E-mail:
slesley@gnf.org
Fax: 858-812-1746
Tel: 858-812-1551
An unexpected substrate-dependent lag-phase, found in the single turnover
A. Mason, N. Agrawal, M. T. Washington, S. A. Lesley and A. Kohen, Chem. Commun., 2006, 1781 DOI: 10.1039/B517881A
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