Issue 10, 2006
From the journal:

Chemical Communications

Characterisation of Streptomyces spheroides NovW and revision of its functional assignment to a dTDP-6-deoxy-d-xylo-4-hexulose 3-epimerase

Mónica Tello,ab   Piotr Jakimowicz,†c   James C. Errey,a   Caren L. Freel Meyers,‡d   Christopher T. Walsh,d   Mark J. Buttner,c   David M. Lawsonb  and  Robert A. Field*a  

* Corresponding authors

a Centre for Carbohydrate Chemistry, University of East Anglia, Norwich, UK
E-mail: r.a.field@uea.ac.uk
Fax: +44-1603-592003

b Department of Biological Chemistry, John Innes Centre, Norwich, UK

c Department of Molecular Microbiology, John Innes Centre, Norwich, UK

d Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, US

Abstract

Characterisation of recombinant Streptomyces spheroides NovW in vitro suggests that it is not a kinetically competent dual action dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase, but possesses only significant 3-epimerase activity.

Graphical abstract: Characterisation of Streptomyces spheroides NovW and revision of its functional assignment to a dTDP-6-deoxy-d-xylo-4-hexulose 3-epimerase

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Article information

DOI
https://doi.org/10.1039/B515763C
Article type
Communication
Submitted
07 Nov 2005
Accepted
14 Dec 2005
First published
24 Jan 2006

Chem. Commun., 2006, 1079-1081

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Characterisation of Streptomyces spheroides NovW and revision of its functional assignment to a dTDP-6-deoxy-D-xylo-4-hexulose 3-epimerase

M. Tello, P. Jakimowicz, J. C. Errey, C. L. Freel Meyers, C. T. Walsh, M. J. Buttner, D. M. Lawson and R. A. Field, Chem. Commun., 2006, 1079 DOI: 10.1039/B515763C

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