Issue 9, 2006
From the journal:

Chemical Communications

Additivity rule holds in the hydrogen transfer reactivity of unsaturated fatty acids with a peroxyl radical: mechanistic insight into lipoxygenase†

Hironori Kitaguchi,a   Kei Ohkubo,a   Seiji Ogoa  and  Shunichi Fukuzumi*a  

* Corresponding authors

a Department of Material and Life Science, Division of Advanced Science and Biotechnology, Graduate School of Engineering, Osaka University, SORST, Japan Science and Technology Agency (JST), Suita, Osaka 565-0871, Japan
E-mail: fukuzumi@chem.eng.osaka-u.ac.jp
Fax: +81-6-6879-7370
Tel: +81-6-6879-7368

Abstract

A simple additivity rule holds in the hydrogen transfer reactivity of unsaturated fatty acids with cumylperoxyl radical, which is expressed by the additive contributions of the reactivity of active hydrogens from the 1,4-pentadiene subunit and those of the allylic subunit; the kinetic isotope effect on the hydrogen transfer reactions (KIE = 6.1) is significantly smaller than that observed for lipoxygenase (KIE = 81).

Graphical abstract: Additivity rule holds in the hydrogen transfer reactivity of unsaturated fatty acids with a peroxyl radical: mechanistic insight into lipoxygenase

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Article information

DOI
https://doi.org/10.1039/B515004C
Article type
Communication
Submitted
24 Oct 2005
Accepted
14 Dec 2005
First published
20 Jan 2006

Chem. Commun., 2006, 979-981

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Additivity rule holds in the hydrogen transfer reactivity of unsaturated fatty acids with a peroxyl radical: mechanistic insight into lipoxygenase

H. Kitaguchi, K. Ohkubo, S. Ogo and S. Fukuzumi, Chem. Commun., 2006, 979 DOI: 10.1039/B515004C

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