Modified α–β chimeric oligoDNA bearing a multi-conjugate of 2,2-bis(hydroxymethyl)propionic acid–anthraquinone–polyamine exhibited improved and stereo-nonspecific triplex-forming ability

Abstract

Novel α–β chimeric oligonucleotides bearing a propionic acid derivative of an anthraquinone–polyamine conjugate in the “linker” region sequence-specifically formed a substantially stable alternate-stranded triplex with dsDNA almost regardless of the stereochemistry of the derivative.