Issue 3, 2006
From the journal:

Chemical Communications

Affinity prediction for substrates of the peptide transporter PepT1†

Patrick D. Bailey,*a   C. A. Richard Boyd,b   Ian D. Collier,‡c   John. P. George,c   George L. Kellett,d   David Meredith,b   Keith M. Morgan,c   Rachel Pettecrewa  and  Richard A. Pricea  

* Corresponding authors

a School of Chemistry, Faraday Building, The University of Manchester, Sackville Street, Manchester, UK
E-mail: pat.bailey@manchester.ac.uk
Fax: +44 (0)161 306 4541
Tel: +44 (0)161 306 4448

b Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, UK
E-mail: richard.boyd@anat.ox.ac.uk
Fax: +44 (0)1865 272 420
Tel: +44 (0)1865 272 169

c School of EPS – Chemistry, Perkin Building, Heriot-Watt University, Edinburgh, UK
E-mail: k.m.morgan@hw.ac.uk
Fax: +44 (0)131 451 3180
Tel: +44 (0)131 451 8020

d Department of Biology, University of York, PO Box 373, York, UK
E-mail: glk1@york.ac.uk
Fax: +44 (0)1904 328 505
Tel: +44 (0)1904 328 500

Abstract

A quantitative method has been developed for determining the affinity of substrates for the peptide transporter PepT1, allowing oral availability of drugs via PepT1 to be estimated.

Graphical abstract: Affinity prediction for substrates of the peptide transporter PepT1

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Article information

DOI
https://doi.org/10.1039/B511996K
Article type
Communication
Submitted
25 Aug 2005
Accepted
27 Oct 2005
First published
30 Nov 2005

Chem. Commun., 2006, 323-325

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Affinity prediction for substrates of the peptide transporter PepT1

P. D. Bailey, C. A. R. Boyd, I. D. Collier, John. P. George, G. L. Kellett, D. Meredith, K. M. Morgan, R. Pettecrew and R. A. Price, Chem. Commun., 2006, 323 DOI: 10.1039/B511996K

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