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Issue 4, 2005
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Molecular assembly of biomimetic microcapsules

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Abstract

Our recent work on the fabrication of microcapsules comprised of human serum albumin (HSA) and L-α-dimyristoylphosphatitic acid (DMPA) by means of stepwise adsorption of HSA and DMPA on fluid droplet surfaces or charged colloids and subsequent dissolution of the cores is reviewed. The lipid self-assembles as a bilayer on the protein surface and the completed microcapsule serves as a biomimetic membrane model. The DMPA/HSA microcapsules have good biocompatibility and the potential for the insertion of recognition units in the lipid bilayers. The structure and properties of the lipid/protein microcapsules are described and their potential for applications in sustained drug release are introduced.

Graphical abstract: Molecular assembly of biomimetic microcapsules

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Article information


Submitted
29 Apr 2005
Accepted
05 Jul 2005
First published
31 Aug 2005

Soft Matter, 2005,1, 259-264
Article type
Review Article

Molecular assembly of biomimetic microcapsules

J. Li, H. Möhwald, Z. An and G. Lu, Soft Matter, 2005, 1, 259
DOI: 10.1039/B506092N

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