Michael, Michael–aldol and Michael–Michael reactions of enolate equivalents of butane-2,3-diacetal protected glycolic acid derivatives

Abstract

Consecutive coupling reactions of butane-2,3-diacetal protected glycolic acid derivatives with Michael acceptors and aldehydes are reported. An enantiopure sample of this building block was used to kinetically resolve a chiral Michael acceptor present as a racemic mixture of enantiomers.