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Issue 18, 2005
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Hydroxyl radical generation via photoreduction of a simple pyridine N-oxide by an NADH analogue

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Abstract

Photoreduction of pyridine N-oxide, which has a key structure of antitumor agents for hypoxic solid tumors, by 1-benzyl-1,4-dihydronicotinamide in deaerated aprotic media resulted in generation of hydroxyl radical, leading to the oxidation of salicylic acid to 2,3- and 2,5-dihydroxybenzoic acids, and catechol.

Graphical abstract: Hydroxyl radical generation via photoreduction of a simple pyridine N-oxide by an NADH analogue

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Publication details

The article was received on 05 Jul 2005, accepted on 22 Jul 2005 and first published on 02 Aug 2005


Article type: Communication
DOI: 10.1039/B509447J
Citation: Org. Biomol. Chem., 2005,3, 3263-3265
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    Hydroxyl radical generation via photoreduction of a simple pyridine N-oxide by an NADH analogue

    I. Nakanishi, C. Nishizawa, K. Ohkubo, K. Takeshita, K. T. Suzuki, T. Ozawa, S. M. Hecht, M. Tanno, S. Sueyoshi, N. Miyata, H. Okuda, S. Fukuzumi, N. Ikota and K. Fukuhara, Org. Biomol. Chem., 2005, 3, 3263
    DOI: 10.1039/B509447J

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