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Issue 11, 2005
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Novel molecular drug carrier: encapsulation of oxaliplatin in cucurbit[7]uril and its effects on stability and reactivity of the drug

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Abstract

Oxaliplatin forms a stable 1 : 1 inclusion complex with cucurbit[7]uril as indicated by NMR, mass spectrometry, isothermal titration calorimetry and X-ray crystallography. The encapsulation of the drug results in a large enhancement in stability, a moderate decrease in reactivity toward guanosine but a much larger decrease in reactivity toward L-methionine, which suggests the encapsulation not only increases the stability of the drug but also may reduce unwanted side effects caused by protein binding of the platinum drug. A preliminary in vitro assay using various tumor cell lines reveals that the encapsulation results in a decrease in the antitumor activity of oxaliplatin.

Graphical abstract: Novel molecular drug carrier: encapsulation of oxaliplatin in cucurbit[7]uril and its effects on stability and reactivity of the drug

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Publication details

The article was received on 31 Mar 2005, accepted on 14 Apr 2005 and first published on 28 Apr 2005


Article type: Paper
DOI: 10.1039/B504487A
Citation: Org. Biomol. Chem., 2005,3, 2122-2125
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    Novel molecular drug carrier: encapsulation of oxaliplatin in cucurbit[7]uril and its effects on stability and reactivity of the drug

    Y. Jin Jeon, S. Kim, Y. Ho Ko, S. Sakamoto, K. Yamaguchi and K. Kim, Org. Biomol. Chem., 2005, 3, 2122
    DOI: 10.1039/B504487A

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