A consecutive four-component synthesis of highly-substituted tetrahydro-β-carbolines 6 can be achieved by a coupling-aminatio-aza-annulation-Pictet–Spengler (CAAPS) sequence creating five new σ-bonds and four new stereocenters in a one-pot fashion. The structures were unambiguously supported by X-ray structure analyses.
A. S. Karpov, F. Rominger and T. J. J. Müller, Org. Biomol. Chem., 2005, 3, 4382 DOI: 10.1039/B511861A
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