Issue 21, 2005
From the journal:

Organic & Biomolecular Chemistry

Synthesis and biological activity of prodruginhibitors of the thioredoxin–thioredoxin reductase system

Peter Wipf,*a   Stephen M. Lynch,a   Garth Powis,†b   Anne Birminghamb  and  Erikah E. Englunda  

* Corresponding authors

a Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, USA
E-mail: pwipf@pitt.edu
Fax: +1-412-624-0787
Tel: +1-412-624-8606

b Arizona Cancer Center, University of Arizona, 1515 North Campbell Avenue, Tucson, AZ, USA

Abstract

A series of palmarumycin prodrugs and water-soluble analogs has been synthesized and assayed for inhibition of the thioredoxin–thioredoxin reductase system. Increased aqueous solubility led to an improved in vivo activity profile.

Graphical abstract: Synthesis and biological activity of prodrug inhibitors of the thioredoxin–thioredoxin reductase system

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Article information

DOI
https://doi.org/10.1039/B510718K
Article type
Communication
Submitted
28 Jul 2005
Accepted
16 Sep 2005
First published
28 Sep 2005

Org. Biomol. Chem., 2005,3, 3880-3882

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Synthesis and biological activity of prodrug inhibitors of the thioredoxin–thioredoxin reductase system

P. Wipf, S. M. Lynch, G. Powis, A. Birmingham and E. E. Englund, Org. Biomol. Chem., 2005, 3, 3880 DOI: 10.1039/B510718K

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