Synthesis and characterisation of estrogenic carriers for cytotoxic Pt(ii) fragments: biological activity of the resulting complexes†
Abstract
This paper describes the synthesis and the spectroscopic characterisation of cis-dichloro[N-(4-(17α-ethynylestradiolyl)-benzyl)-ethylenediamine]platinum(II) and cis-diamino[2-(4-(17α-ethynylestradiolyl)-benzoylamino)-malonato]platinum(II). These complexes were synthesised in good yield according to multi-step procedures based on the classical and non-classical Sonogashira coupling reaction, respectively. These compounds retain an acceptable degree of relative binding affinity (RBA) for the α form of