Issue 19, 2005
From the journal:

Organic & Biomolecular Chemistry

Structural arrangement of DNA constrained by a cross-linker

Masayuki Endo*a  and  Tetsuro Majima*a  

* Corresponding authors

a The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka, Japan
E-mail: endo@sanken.osaka-u.ac.jp, majima@sanken.osaka-u.ac.jp
Fax: +81-6-6879-8499
Tel: +81-6-6879-8495

Abstract

Self-complementary cross-linked oligonucleotides with a disulfide linkage were designed and synthesized. Double helix and hairpin structures were controlled using the different diastereochemistry of phosphoramidate where the cross-linker was introduced. The structures of the strained cross-linked DNAs were estimated by gel mobility, circular dichroism spectra, and melting profiles.

Graphical abstract: Structural arrangement of DNA constrained by a cross-linker

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Article information

DOI
https://doi.org/10.1039/B507126G
Article type
Communication
Submitted
20 May 2005
Accepted
22 Aug 2005
First published
02 Sep 2005

Org. Biomol. Chem., 2005,3, 3476-3478

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Structural arrangement of DNA constrained by a cross-linker

M. Endo and T. Majima, Org. Biomol. Chem., 2005, 3, 3476 DOI: 10.1039/B507126G

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