Wang-aldehyde resin as a recyclable support for the synthesis of α,α-disubstituted amino acid derivatives

Abstract

Merrifield resin was functionalised with hydroxybenzaldehyde under microwave irradiation. The resultant resin was used as a means for immobilisation and activation of α-amino acid esters for alkylation reactions. α,α-Disubstituted and cyclic amino acid esters were prepared in good yields.