Issue 16, 2005
From the journal:

Organic & Biomolecular Chemistry

Model studies for the synthesis of galbonolide B†‡

James Eshelby,b   Matthias Goessman,a   Philip J. Parsons,*a   Lewis Pennicotta  and  Adrian Hightonc  

* Corresponding authors

a Department of Chemistry, The University of Sussex, Falmer, Brighton
E-mail: P.J.Parsons@sussex.ac.uk
Fax: 01273 677196
Tel: 01273 678861

b Pfizer Pharmaceuticals Limited, Sandwich, Kent

c AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire

Abstract

The construction of the fourteen membered ring present in galbonolide B 1 is reported. The 10,11-diene system present in the southern portion of 1 has been constructed using an ester enolate rearrangement/silicon mediated fragmentation cascade, whilst the macrocycle has been synthesised following a Johnson rearrangement/mercury assisted ring closure protocol.

Graphical abstract: Model studies for the synthesis of galbonolide B

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B505378A
Article type
Paper
Submitted
18 Apr 2005
Accepted
09 Jun 2005
First published
04 Jul 2005

Org. Biomol. Chem., 2005,3, 2994-2997

Permissions

Request permissions

Model studies for the synthesis of galbonolide B

J. Eshelby, M. Goessman, P. J. Parsons, L. Pennicott and A. Highton, Org. Biomol. Chem., 2005, 3, 2994 DOI: 10.1039/B505378A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements