Issue 8, 2005

Towards multifunctional antioxidants: synthesis, electrochemistry, in vitro and cell culture evaluation of compounds with ligand/catalytic properties

Abstract

Numerous human diseases are linked to a biochemical condition known as oxidative stress (OS). Antioxidants are therefore becoming increasingly important as potential disease prevention and therapeutic agents. Since OS is a multi-stressor event, agents combining a range of different antioxidant properties, such as redox catalysis and metal binding, might be more effective and selective than mono-functional agents. Selenium derivatives of aniline and pyridine combine redox activity with metal binding properties. These multifunctional agents have a distinct electrochemical profile, and exhibit good catalytic activity in the glutathione peroxidase mimic and metallothionein assays. They also show antioxidant activity in a skin cell model of UVA-induced stress. These compounds might therefore provide the basis for novel agents combining two or more distinct antioxidant properties.

Graphical abstract: Towards multifunctional antioxidants: synthesis, electrochemistry, in vitro and cell culture evaluation of compounds with ligand/catalytic properties

Article information

Article type
Paper
Submitted
04 Mar 2005
Accepted
04 Mar 2005
First published
18 Mar 2005

Org. Biomol. Chem., 2005,3, 1541-1546

Towards multifunctional antioxidants: synthesis, electrochemistry, in vitro and cell culture evaluation of compounds with ligand/catalytic properties

C. A. Collins, F. H. Fry, A. L. Holme, A. Yiakouvaki, A. Al-Qenaei, C. Pourzand and C. Jacob, Org. Biomol. Chem., 2005, 3, 1541 DOI: 10.1039/B503282M

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