Issue 8, 2005

Development of new calcium receptors based on oxazolidin-2-ones containing pseudopeptides

Abstract

With the aim of designing a new calcium receptor, the synthesis and the conformational analysis of a small library of dipeptides having the general formula Ac–Oxx–L-Xaa–OBn [Oxx = L-Oxd, (4S,5R)-4-methyl-5-carboxyoxazolidin-2-one; D-Oxd, (4R,5S)-4-methyl-5-carboxyoxazolidin-2-one; or D-Oxac (4R)-(2-oxo-1,3-oxazolidin-4-yl)-acetic acid] is reported. Ac–L-Oxd–L-Ala–OBn was identified as the most promising compound by MS–ESI analysis and this outcome was confirmed by photoluminescence spectroscopy.

Graphical abstract: Development of new calcium receptors based on oxazolidin-2-ones containing pseudopeptides

Article information

Article type
Paper
Submitted
21 Jan 2005
Accepted
03 Mar 2005
First published
17 Mar 2005

Org. Biomol. Chem., 2005,3, 1520-1524

Development of new calcium receptors based on oxazolidin-2-ones containing pseudopeptides

G. Luppi, A. Garelli, L. Prodi, Q. B. Broxterman, B. Kaptein and C. Tomasini, Org. Biomol. Chem., 2005, 3, 1520 DOI: 10.1039/B501017A

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