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Issue 8, 2005
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A chiral molecular recognition approach to the formation of optically active quaternary centres in aza-Henry reactions

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Abstract

An approach to asymmetric catalysis based on chiral molecular recognition by the combination of chiral Lewis acids and chiral organocatalysis for the formation of optically active quarternary centers in the aza-Henry reaction is presented; this procedure leads to products with up to 98% ee and a diastereomeric ratio of 14 : 1 in excellent yields with catalyst loadings of 5 mol%.

Graphical abstract: A chiral molecular recognition approach to the formation of optically active quaternary centres in aza-Henry reactions

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Article information


Submitted
13 Jan 2005
Accepted
28 Feb 2005
First published
10 Mar 2005

Org. Biomol. Chem., 2005,3, 1362-1364
Article type
Communication

A chiral molecular recognition approach to the formation of optically active quaternary centres in aza-Henry reactions

K. R. Knudsen and K. A. Jørgensen, Org. Biomol. Chem., 2005, 3, 1362
DOI: 10.1039/B500618J

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