Issue 4, 2005
From the journal:

Organic & Biomolecular Chemistry

Synthesis of homogenous site-selectively glycosylated proteins

Richard S. Swanwick,a   Alison M. Daines,b   Sabine L. Flitschb  and  Rudolf K. Allemann*a  

* Corresponding authors

a School of Chemistry, University of Birmingham, Edgbaston, Birmingham, UK
E-mail: r.k.allemann@bam.ac.uk
Fax: 41 121 4147871
Tel: 41 121 4144359

b School of Chemistry, University of Edinburgh, King's Buildings, West Mains Road, Edinburgh, UK
E-mail: s.flitsch@ed.ac.uk
Fax: 44 131 6504737
Tel: 44 131 6504737

Abstract

Apparently homogenous glycoproteins can be synthesised in good yield by a combination of site directed mutagenesis, a highly flexible but selective chemical derivatisation and efficient purification through the use of glycosyl thiosulfonates such as 2-((biotinoyl)-amino)-ethyl methanethiosulfonate.

Graphical abstract: Synthesis of homogenous site-selectively glycosylated proteins

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Article information

DOI
https://doi.org/10.1039/B417133K
Article type
Communication
Submitted
10 Nov 2004
Accepted
06 Dec 2004
First published
24 Dec 2004

Org. Biomol. Chem., 2005,3, 572-574

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Synthesis of homogenous site-selectively glycosylated proteins

R. S. Swanwick, A. M. Daines, S. L. Flitsch and R. K. Allemann, Org. Biomol. Chem., 2005, 3, 572 DOI: 10.1039/B417133K

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