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Issue 3, 2005
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Cucurbitacins and cucurbitane glycosides: structures and biological activities

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Abstract

Covering: 1980 to August 2004

The natural cucurbitacins constitute a group of triterpenoid substances which are well-known for their bitterness and toxicity. Structurally, they are characterized by the tetracyclic cucurbitane nucleus skeleton, namely, 19-(10→9β)-abeo-10α-lanost-5-ene (also known as 9β-methyl-19-norlanosta-5-ene), with a variety of oxygen substitutions at different positions. According to the characteristics of their structures, cucurbitacins are divided into twelve categories. The biological effects of the cucurbitacins are also covered.

Graphical abstract: Cucurbitacins and cucurbitane glycosides: structures and biological activities

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Submitted
15 Dec 2004
First published
04 Apr 2005

Nat. Prod. Rep., 2005,22, 386-399
Article type
Review Article

Cucurbitacins and cucurbitane glycosides: structures and biological activities

J. C. Chen, M. H. Chiu, R. L. Nie, G. A. Cordell and S. X. Qiu, Nat. Prod. Rep., 2005, 22, 386
DOI: 10.1039/B418841C

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