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Issue 3, 2005
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Biosynthesis of flavocoenzymes

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Abstract

The biosynthesis of one riboflavin molecule requires one molecule of GTP and two molecules of ribulose 5-phosphate. The imidazole ring of GTP is hydrolytically opened, yielding a 2,5-diaminopyrimidine that is converted to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione by a sequence of deamination, side chain reduction, and dephosphorylation. Condensation of 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione with 3,4-dihydroxy-2-butanone 4-phosphate obtained from ribulose 5-phosphate affords 6,7-dimethyl-8-ribityllumazine. Dismutation of the lumazine derivative yields riboflavin and 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione, which is recycled in the biosynthetic pathway. The enzymes of the riboflavin pathway are potential targets for antibacterial agents.

Graphical abstract: Biosynthesis of flavocoenzymes

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Article information


Submitted
07 Mar 2005
First published
21 Apr 2005

Nat. Prod. Rep., 2005,22, 324-350
Article type
Review Article

Biosynthesis of flavocoenzymes

M. Fischer and A. Bacher, Nat. Prod. Rep., 2005, 22, 324
DOI: 10.1039/B210142B

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