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Issue 9, 2005
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Does it bind? An instant binding assay for DNA oligonucleotide interactive small molecules

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Abstract

Ultrafiltration analysis has been used to screen DNA oligonucleotide interactive small molecules for the first time, providing an almost instantaneous indication of the binding affinity, and was used to identify a new class of DNA interactive molecules based on a range of dihydro-imidazo-phenanthridinium-based framework; this methodology provides a straightforward yes/no answer to small molecule DNA binding.

Graphical abstract: Does it bind? An instant binding assay for DNA oligonucleotide interactive small molecules

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Article information


Submitted
19 May 2005
Accepted
11 Jul 2005
First published
25 Jul 2005

New J. Chem., 2005,29, 1118-1120
Article type
Letter

Does it bind? An instant binding assay for DNA oligonucleotide interactive small molecules

L. V. Smith, J. M. de la Fuente, K. M. Guthrie, A. D. C. Parenty and L. Cronin, New J. Chem., 2005, 29, 1118
DOI: 10.1039/B507037F

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