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Issue 6, 2005
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Glass microfluidic devices with thin membrane voltage junctions for electrospray mass spectrometry

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Abstract

In this study a novel glass membrane was prepared for conducting high voltage (HV) to solution in the channel of a microfabricated device for generation of liquid electrospray. Taylor cone formation and mass spectra obtained from this microdevice confirmed the utility of the glass membrane, but voltage conduction through the membrane could not be successfully explained based solely on the conductivity of the glass itself. This novel method for developing a high-voltage interface for microdevices avoids direct metal/liquid contact eliminating bubble formation in the channel due to water hydrolysis on the surface of the metal. Further, this arrangement produces no dead volume as is often found with traditional liquid junctions. At the same time, preliminary investigations into the outlet design of glass microdevices for interfacing with electrospray mass spectrometry, was explored. Both the exit shape and the use of hydrophobic coatings at the channel exit of the microdevice electrospray interface were evaluated using standard proteins with results indicating the utility of this type of design after further optimization.

Graphical abstract: Glass microfluidic devices with thin membrane voltage junctions for electrospray mass spectrometry

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Publication details

The article was received on 17 Feb 2005, accepted on 13 Apr 2005 and first published on 29 Apr 2005


Article type: Paper
DOI: 10.1039/B502446C
Citation: Lab Chip, 2005,5, 619-627
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    Glass microfluidic devices with thin membrane voltage junctions for electrospray mass spectrometry

    G. E. Yue, M. G. Roper, E. D. Jeffery, C. J. Easley, C. Balchunas, J. P. Landers and J. P. Ferrance, Lab Chip, 2005, 5, 619
    DOI: 10.1039/B502446C

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