Issue 8, 2005
From the journal:

Lab on a Chip

Controllable polymerization of N-carboxy anhydrides in a microreaction system†

Takeshi Honda,a   Masaya Miyazaki,*ab   Hiroyuki Nakamuraa  and  Hideaki Maeda*ab  

* Corresponding authors

a Nanotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 807-1, Shuku, Tosu, Saga, Japan
E-mail: m.miyazaki@aist.go.jp, maeda-h@aist.go.jp
Fax: +81-942-81-3657
Tel: +81-942-81-3675

b Department of Molecular and Material Sciences, Interdisciplinary Graduate School of Engineering Sciences, Kyushu University, Kasuga, Fukuoka, Japan

Abstract

We have developed a microfluidic system for polymerization of amino acid N-carboxyanhydride and compared the properties of the products with those obtained by batchwise system under various experimental conditions. It was found that the microreactor produced polymers with narrower molecular weight distribution compared with polymers obtained by the batchwise system. Also, the molecular mass of the polymer produced using the microreactor was simply governed by the flow (pumping) rate. These results indicated that the microreactor could be a model for synthesis of amino acid polymer with highly controllable average molecular weight and molecular weight distribution.

Graphical abstract: Controllable polymerization of N-carboxy anhydrides in a microreaction system

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Article information

DOI
https://doi.org/10.1039/B505137A
Article type
Paper
Submitted
12 Apr 2005
Accepted
08 Jun 2005
First published
01 Jul 2005

Lab Chip, 2005,5, 812-818

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Controllable polymerization of N-carboxy anhydrides in a microreaction system

T. Honda, M. Miyazaki, H. Nakamura and H. Maeda, Lab Chip, 2005, 5, 812 DOI: 10.1039/B505137A

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