Issue 35-36, 2005
From the journal:

Journal of Materials Chemistry

Hybrid materials applied to biotechnologies: coating of calcium phosphates for the design of implants active against bone resorption disorders

Hélène Roussière,ab   Gilles Montavon,*c   Samia Laïb,a   Pascal Janvier,a   Bruno Alonso,d   Franck Fayon,d   Marc Petit,a   Dominique Massiot,d   Jean-Michel Bouler*b  and  Bruno Bujoli*a  

* Corresponding authors

a Laboratoire de Synthèse Organique, UMR CNRS 6513 and FR CNRS 2465, 2 Rue de la Houssinière, BP92208, Nantes Cedex 3, France
E-mail: bujoli@chimie.univ-nantes.fr
Fax: +33 251125402

b Matériaux d'Intérêt Biologique, EM INSERM 99-03, Faculté de Chirurgie Dentaire, BP84215, Nantes Cedex 1, France

c Laboratoire de Physique Subatomique et des Technologies Associées, UMR CNRS 6457, Ecole des Mines de Nantes, 4 Rue Alfred KASTLER, BP 20722, Nantes Cedex 03, France

d CRMHT, UPR CNRS 4212, 1D Avenue de la Recherche Scientifique, Orléans Cedex 02, France

Abstract

The reaction of a bisphosphonate bone resorption inhibitor (Zoledronate) with calcium deficient hydroxyapatites (CDAs) was studied as a potential route to local drug delivery systems active against bone resorption disorders. A simple mathematical model of the Zoledronate–CDA interaction was designed that correctly described the adsorption of Zoledronate onto CDAs. The resulting Zoledronate-loaded materials were found to release the drug in different phosphate-containing media, with a satisfactory agreement between experimental data and the values predicted from the model.

Graphical abstract: Hybrid materials applied to biotechnologies: coating of calcium phosphates for the design of implants active against bone resorption disorders

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Article information

DOI
https://doi.org/10.1039/B503680A
Article type
Paper
Submitted
11 Mar 2005
Accepted
13 Jun 2005
First published
01 Jul 2005

J. Mater. Chem., 2005,15, 3869-3875

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Hybrid materials applied to biotechnologies: coating of calcium phosphates for the design of implants active against bone resorption disorders

H. Roussière, G. Montavon, S. Laïb, P. Janvier, B. Alonso, F. Fayon, M. Petit, D. Massiot, J. Bouler and B. Bujoli, J. Mater. Chem., 2005, 15, 3869 DOI: 10.1039/B503680A

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