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Volume 128, 2005
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Design of chimaeric polymersomes

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We discuss the development of hierarchical polymer particles, or variegated polymersome composites, in which at least two different components are phase separated within one polymersome chimaera. We briefly discuss the present status in experimental polymersome research, and then discuss a speculative design strategy, based on mesoscopic simulations with a dynamical variant of polymer self-consistent field theory (Mesodyn). The main conclusion is that the counter-intuitive co-assembly of demixing block copolymers is the key in controlling hierarchical structures on a mesoscopic scale. This is the classical paradox of a chimaera: the constituents live in the same scaffold, but apart. Block copolymers beyond a certain length will always split the assembly, and without further precautions, polymer based chimaerae are intrinsically unstable. To this end, we propose the application of a branched block copolymer as composite compatibilizer, glueing the separate domains together, and thereby stabilizing the chimaeric polymersome.

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Publication details

The article was received on 01 Mar 2004, accepted on 19 May 2004 and first published on 29 Oct 2004

Article type: Paper
DOI: 10.1039/B403187C
Citation: Faraday Discuss., 2005,128, 355-361
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    Design of chimaeric polymersomes

    J. G. E. M. Fraaije, C. A. van Sluis, A. Kros, A. V. Zvelindovsky and G. J. A. Sevink, Faraday Discuss., 2005, 128, 355
    DOI: 10.1039/B403187C

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