Evidence for a hydrogen abstraction mechanism in P450-catalyzed N-dealkylations

Mehul Bhakta; Paul F. Hollenberg; Kandatege Wimalasena

doi:10.1039/B412221F

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Evidence for a hydrogen abstraction mechanism in P₄₅₀-catalyzed N-dealkylations†

Mehul Bhakta,^a Paul F. Hollenberg^b and Kandatege Wimalasena*^a

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* Corresponding authors

^a Department of Chemistry, Wichita State University, Wichita, Kansas, USA
E-mail: kandatege.wimalasena@wichita.edu
Fax: 316-978-3431
Tel: 316-978-7386

^b Department of Pharmacology, The University of Michigan, Ann Arbor, Michigan, USA
E-mail: phollen@umich.edu
Fax: 734-763-4450
Tel: 734-764-8166

Abstract

The experimental evidence presented in this manuscript suggest against the widely accepted single electron/proton transfer mechanism for P₄₅₀ catalyzed N-dealkylations and provides strong support for a hydrogen atom abstraction mechanism.

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Supplementary files

GC-MS chromatograms and experimental details PDF (454K)

Article information

DOI: https://doi.org/10.1039/B412221F
Article type: Communication
Submitted: 09 Aug 2004
Accepted: 23 Sep 2004
First published: 24 Nov 2004

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Chem. Commun., 2005, 265-267

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Evidence for a hydrogen abstraction mechanism in P₄₅₀-catalyzed N-dealkylations

M. Bhakta, P. F. Hollenberg and K. Wimalasena, Chem. Commun., 2005, 265 DOI: 10.1039/B412221F

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