Issue 46, 2005
From the journal:

Chemical Communications

Expanding functionality of RNA: synthesis and properties of RNA containing imidazole modified tandem G–U wobble base pairs†

Eriks Rozners,*a   Romualdas Smiciusa  and  Chika Uchiyamaa  

* Corresponding authors

a Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, USA
E-mail: e.rozners@neu.edu
Fax: 1-617-373-8795
Tel: 1-617-373-5826

Abstract

Imidazole modification at C-5 of uridine that is part of tandem G–U wobble base pairs causes slight reduction of thermal stability (ΔΔG0310 < 0.4 kcal mol−1) and relatively small change in hydration of short RNA helices.

Graphical abstract: Expanding functionality of RNA: synthesis and properties of RNA containing imidazole modified tandem G–U wobble base pairs

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Article information

DOI
https://doi.org/10.1039/B510846B
Article type
Communication
Submitted
29 Jul 2005
Accepted
27 Sep 2005
First published
20 Oct 2005

Chem. Commun., 2005, 5778-5780

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Expanding functionality of RNA: synthesis and properties of RNA containing imidazole modified tandem G–U wobble base pairs

E. Rozners, R. Smicius and C. Uchiyama, Chem. Commun., 2005, 5778 DOI: 10.1039/B510846B

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