Issue 43, 2005
From the journal:

Chemical Communications

Unprecedented asymmetric induction through configurationally stable lithium N-(α-methylbenzyl)phosphinamides. A new entry to enantiomerically pure γ-aminophosphinic acids and esters†‡

Ignacio Fernández,a   Gloria Ruiz Gómez,a   Ignacio Alfonso,b   María J. Iglesiasa  and  Fernando López Ortiz*a  

* Corresponding authors

a Área de Química Orgánica, Universidad de Almería, Carretera de Sacramento, 04120, Almería, Spain
E-mail: flortiz@ual.es

b Departamento de Química Inorgánica y Orgánica, Universidad Jaume I, Castellón, Spain

Abstract

The first examples of configurationally stable N-benzyl-N-phosphinoyl carbanions are described. Their applications to the synthesis of homochiral γ-aminophosphinic acids and esters via highly enantioselective dearomatising reactions are shown.

Graphical abstract: Unprecedented asymmetric induction through configurationally stable lithium N-(α-methylbenzyl)phosphinamides. A new entry to enantiomerically pure γ-aminophosphinic acids and esters

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Article information

DOI
https://doi.org/10.1039/B510685K
Article type
Communication
Submitted
27 Jul 2005
Accepted
09 Sep 2005
First published
30 Sep 2005

Chem. Commun., 2005, 5408-5410

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Unprecedented asymmetric induction through configurationally stable lithium N-(α-methylbenzyl)phosphinamides. A new entry to enantiomerically pure γ-aminophosphinic acids and esters

I. Fernández, G. R. Gómez, I. Alfonso, M. J. Iglesias and F. L. Ortiz, Chem. Commun., 2005, 5408 DOI: 10.1039/B510685K

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