Direct asymmetric aldol-Tishchenko reaction of aliphatic ketones catalyzed by syn-aminoalcohol–Yb(iii) complexes

Abstract

The asymmetric direct aldol condensation of aldehydes with ethyl- and propylketones is catalyzed by syn-α-aminoalcohol–Yb(OTf)₃ complexes, yielding the anti-1,3-diol monoesters with high diastereocontrol and good enantioselectivity. Three adjacent stereogenic centers are created in a simultaneous aldol condensation and Evans–Tishchenko reduction in an acyclic system.