Issue 42, 2005
From the journal:

Chemical Communications

The direct α-zincation of amides, phosphonates and phosphine oxides by H–Zn exchange†

Mark L. Hlavinka,a   Jeffrey F. Grecoa  and  John R. Hagadorn*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado, USA
E-mail: hagadorn@colorado.edu
Fax: +1 303 492 5894
Tel: +1 303 492 5717

Abstract

Stoichiometric or catalytic quantities of simple 2° amines greatly increase the rate of H–Zn exchange between ZnPh2 and a range of relatively non-acidic substrates, allowing for the convenient and direct preparation of α-functionalized organozincs.

Graphical abstract: The direct α-zincation of amides, phosphonates and phosphine oxides by H–Zn exchange

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Article information

DOI
https://doi.org/10.1039/B509190J
Article type
Communication
Submitted
28 Jun 2005
Accepted
07 Sep 2005
First published
23 Sep 2005

Chem. Commun., 2005, 5304-5306

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The direct α-zincation of amides, phosphonates and phosphine oxides by H–Zn exchange

M. L. Hlavinka, J. F. Greco and J. R. Hagadorn, Chem. Commun., 2005, 5304 DOI: 10.1039/B509190J

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