Issue 39, 2005
From the journal:

Chemical Communications

Stereoselective synthesis of (2S,3S,4R,5S)-5-methylpyrrolidine-3,4-diol derivatives that are highly selective α-l-fucosidase inhibitors†

Antonio J. Moreno-Vargas,a   Ana T. Carmona,a   Federico Mora,a   Pierre Vogelb  and  Inmaculada Robina*a  

* Corresponding authors

a Department of Organic Chemistry, Faculty of Chemistry, University of Seville, P. O. Box 553, E-41071 Seville, Spain
E-mail: robina@us.es
Fax: +34954624960
Tel: +34954557151

b Laboratoire de glycochimie et synthèse asymétrique, Swiss Federal Institute of Technology (EPFL), BCH-EPFL, CH-1015 Lausanne, Switzerland
E-mail: pierre.vogel@epfl.ch

Abstract

N-Phenylaminomethyl benzimidazolyl moieties attached at C-2 of (2S,3S,4R,5S)-5-methylpyrrolidine-3,4-diol increase the potency and selectivity of the inhibitory activity of these systems towards α-L-fucosidases.

Graphical abstract: Stereoselective synthesis of (2S,3S,4R,5S)-5-methylpyrrolidine-3,4-diol derivatives that are highly selective α-l-fucosidase inhibitors

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Article information

DOI
https://doi.org/10.1039/B508855K
Article type
Communication
Submitted
24 Jun 2005
Accepted
21 Jul 2005
First published
08 Sep 2005

Chem. Commun., 2005, 4949-4951

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Stereoselective synthesis of (2S,3S,4R,5S)-5-methylpyrrolidine-3,4-diol derivatives that are highly selective α-L-fucosidase inhibitors

A. J. Moreno-Vargas, A. T. Carmona, F. Mora, P. Vogel and I. Robina, Chem. Commun., 2005, 4949 DOI: 10.1039/B508855K

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