Issue 30, 2005
From the journal:

Chemical Communications

Sterically-controlled regioselective para-substitutions of aniline†

Philip W. Dyer,*ab   John Fawcett,b   Gerald A. Griffith,b   Martin J. Hanton,bc   Céline Olivier,b   Adam R. Pattersona  and  Samuel Suharda  

* Corresponding authors

a Department of Chemistry, University of Durham, South Road, Durham, UK
E-mail: p.w.dyer@durham.ac.uk
Fax: +44 (0) 191 384 4737
Tel: +44 (0) 191 334 2150

b Department of Chemistry, University of Leicester, University Road, Leicester, UK

c Sasol Technology UK, Purdie Building, North Haugh, St. Andrews, Fife, UK

Abstract

Introduction of sterically demanding 1-isopropyl-2-methylpropyl or triisopropylsilyl groups at the nitrogen of aniline allows high-yielding regioselective para-substitution to be achieved using a lithiation/substitution sequence.

Graphical abstract: Sterically-controlled regioselective para-substitutions of aniline

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Article information

DOI
https://doi.org/10.1039/B506824J
Article type
Communication
Submitted
13 May 2005
Accepted
27 May 2005
First published
24 Jun 2005

Chem. Commun., 2005, 3835-3837

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Sterically-controlled regioselective para-substitutions of aniline

P. W. Dyer, J. Fawcett, G. A. Griffith, M. J. Hanton, C. Olivier, A. R. Patterson and S. Suhard, Chem. Commun., 2005, 3835 DOI: 10.1039/B506824J

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