Issue 29, 2005
From the journal:

Chemical Communications

Identification of broad specificity P450CAM variants by primary screening against indole as substrate

Ayhan Çelik,a   Robert E. Speighta  and  Nicholas J. Turner*a  

* Corresponding authors

a School of Chemistry, University of Edinburgh, King's Buildings, West Mains Road, Edinburgh, UK
E-mail: n.j.turner@ed.ac.uk
Fax: +44 131 6504719

Abstract

High-throughput screening of cytochrome P450CAM libraries, for their ability to oxidise indole to indigo and indirubin, has resulted in the identification of variants with activity towards the structurally unrelated substrate diphenylmethane.

Graphical abstract: Identification of broad specificity P450CAM variants by primary screening against indole as substrate

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Article information

DOI
https://doi.org/10.1039/B506156C
Article type
Communication
Submitted
04 May 2005
Accepted
24 Jun 2005
First published
05 Jul 2005

Chem. Commun., 2005, 3652-3654

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Identification of broad specificity P450CAM variants by primary screening against indole as substrate

A. Çelik, R. E. Speight and N. J. Turner, Chem. Commun., 2005, 3652 DOI: 10.1039/B506156C

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