Fine tuning the structure of the Cu2+ complex with the prion protein chicken repeat by proline isomerization

Paweł Stańczak; Daniela Valensin; Paulina Juszczyk; Zbigniew Grzonka; Gianni Valensin; Francesca Bernardi; Elena Molteni; Elena Gaggelli; Henryk Kozłowski

doi:10.1039/B504986E

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Fine tuning the structure of the Cu²⁺ complex with the prion protein chicken repeat by proline isomerization†

Paweł Stańczak,^a Daniela Valensin,^b Paulina Juszczyk,^c Zbigniew Grzonka,^c Gianni Valensin,*^b Francesca Bernardi,^b Elena Molteni,^b Elena Gaggelli^b and Henryk Kozłowski*^a

Author affiliations

* Corresponding authors

^a Faculty of Chemistry, University of Wrocław, F. Joliot-Curie 14, Poland
E-mail: henrykoz@wchuwr.chem.uni.wroc.pl

^b Department of Chemistry, University of Siena, via Aldo Moro, Italy
E-mail: valensin@unisi.it

^c Faculty of Chemistry, University of Gdansk, Gdansk, Poland

Abstract

The interaction between the single hexarepeat unit of chicken prion protein [ChPrP(54–59)] and Cu(II) was investigated by NMR, finding different coordination modes for the trans/trans and cis/trans isomers.

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Supplementary files

Peptide synthesis, NMR measurements and ¹H- ¹³C HSQC spectra PDF (125K)

Article information

DOI: https://doi.org/10.1039/B504986E
Article type: Communication
Submitted: 13 Apr 2005
Accepted: 13 May 2005
First published: 01 Jun 2005

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Chem. Commun., 2005, 3298-3300

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Fine tuning the structure of the Cu²⁺ complex with the prion protein chicken repeat by proline isomerization

P. Stańczak, D. Valensin, P. Juszczyk, Z. Grzonka, G. Valensin, F. Bernardi, E. Molteni, E. Gaggelli and H. Kozłowski, Chem. Commun., 2005, 3298 DOI: 10.1039/B504986E

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