Photoinduced DNA end capping viaN3-methyl-5-cyanovinyl-2′-deoxyuridine

Kenzo Fujimoto; Yoshinaga Yoshimura; Tadayoshi Ikemoto; Akio Nakazawa; Masayuki Hayashi; Isao Saito

doi:10.1039/B504162G

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Photoinduced DNA end capping viaN³-methyl-5-cyanovinyl-2′-deoxyuridine†

Kenzo Fujimoto,*^ab Yoshinaga Yoshimura,^b Tadayoshi Ikemoto,^a Akio Nakazawa,^c Masayuki Hayashi^c and Isao Saito^c

Author affiliations

* Corresponding authors

^a The School of Materials Science, Japan Advanced Institute of Science and Technology, Ishikawa, Japan
E-mail: kenzo@jaist.ac.jp
Fax: +81 761 51 1671
Tel: +81 761 51 1671

^b PRESTO, Japan Science and Technology Agency, Ishikawa, Japan

^c Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Kyoto, Japan

Abstract

A modified oligodeoxynucleotide (ODN) containing N³-methyl-5-cyanovinyl-2′-deoxyuridine reacts by photoirradiation at 366 nm with an adenine residue of a complementary template ODN to yield an end-capped ODN in 87% yield.

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Supplementary files

Experimental details PDF (168K)

Article information

DOI: https://doi.org/10.1039/B504162G
Article type: Communication
Submitted: 23 Mar 2005
Accepted: 26 Apr 2005
First published: 24 May 2005

Download Citation

Chem. Commun., 2005, 3177-3179

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Photoinduced DNA end capping viaN³-methyl-5-cyanovinyl-2′-deoxyuridine

K. Fujimoto, Y. Yoshimura, T. Ikemoto, A. Nakazawa, M. Hayashi and I. Saito, Chem. Commun., 2005, 3177 DOI: 10.1039/B504162G

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