Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha

Rong-Tao Li; Quan-Bin Han; Yong-Tang Zheng; Rui-Rui Wang; Liu-Meng Yang; Yang Lu; Su-Qin Sang; Qi-Tai Zheng; Qin-Shi Zhao; Han-Dong Sun

doi:10.1039/B501932J

Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha†

Rong-Tao Li,^a Quan-Bin Han,^a Yong-Tang Zheng,^b Rui-Rui Wang,^b Liu-Meng Yang,^b Yang Lu,^c Su-Qin Sang,^c Qi-Tai Zheng,^c Qin-Shi Zhao^a and Han-Dong Sun*^a

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* Corresponding authors

^a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
E-mail: hdsun@mail.kib.ac.cn
Fax: 86-871-5216343
Tel: 86-871-5223251

^b Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, P. R. China

^c Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing, P. R. China

Abstract

Two new highly oxygenated nortriterpenoids with a unique norcycloartane skeleton, micrandilactones B and C (1–2), were isolated from Schisandra micrantha; micrandilactone C (2) exhibited an EC₅₀ value of 7.71 µg/mL (SI > 25.94) against HIV-1 replication with minimal cytotoxicity, and the potent anti-HIV-1 activity and unique structural features of 2 make it a promising lead for therapeutic development of a new generation of anti-HIV drug.

Chemical Communications

Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha†

Abstract

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Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha

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