Site directed maleimide bifunctional chelators for the M(CO)3+ core (M = 99mTc, Re)

Abstract

A series of bifunctional chelates containing a tridentate donor set for complexation of the M(CO)₃⁺ core and a maleimide group for site-specific coupling to peptides and proteins containing free thiol groups has been prepared and their Re(CO)₃⁺ complexes and glutathione conjugates structurally characterized. The flexibility of design allows preparation of ligands suitable for both fluorescence imaging, radioimaging and radiotherapeutic studies of proteins and peptides as well as other biopolymers using site specific conjugation.