Issue 12, 2005
From the journal:

Chemical Communications

Metalloantimalarials: synthesis and characterization of a novel agent possessing activity against Plasmodium falciparum†

Joseph A. Ocheskey,a   Scott E. Harpstrite,a   Anna Oksman,bc   Daniel E. Goldbergbc  and  Vijay Sharma*a  

* Corresponding authors

a Mallinckrodt Institute of Radiology, Washington University Medical School, St. Louis, MO, USA
E-mail: sharmav@mir.wustl.edu
Fax: 314 362 0152
Tel: 314 362 9358

b Howard Hughes Medical Institute, Washington University Medical School, St. Louis, MO, USA

c Departments of Medicine and Molecular Microbiology, Washington University Medical School, St. Louis, MO, USA

Abstract

The synthesis, characterization, and antimalarial potency of an amine-phenol complex of gallium(III), [{1,12-bis(2-hydroxy-3-methoxy-5-(quinolin-3-yl)-benzyl)-1,5,8,12-tetraazadodecane}-gallium(III)]+, [Ga-3-M-5-Quadd]+ (7) is described; a novel agent that targets Plasmodium falciparum strains.

Graphical abstract: Metalloantimalarials: synthesis and characterization of a novel agent possessing activity against Plasmodium falciparum

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Article information

DOI
https://doi.org/10.1039/B415771K
Article type
Communication
Submitted
13 Oct 2004
Accepted
15 Dec 2004
First published
27 Jan 2005

Chem. Commun., 2005, 1622-1624

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Metalloantimalarials: synthesis and characterization of a novel agent possessing activity against Plasmodium falciparum

J. A. Ocheskey, S. E. Harpstrite, A. Oksman, D. E. Goldberg and V. Sharma, Chem. Commun., 2005, 1622 DOI: 10.1039/B415771K

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