Issue 14, 2005

Fluorescent dendrimers with a peptide cathepsin B cleavage site for drug delivery applications

Abstract

The synthesis of a multifunctionally equipped first generation (G1) dendrimer carrying a pentapeptide with a cathepsin B cleavage site, chelating ligands for Pt2+-complexation, and a dansyl fluorescence marker is described and an investigation of its cellular uptake as well as intracellular localization by confocal fluorescence microscopy reported.

Graphical abstract: Fluorescent dendrimers with a peptide cathepsin B cleavage site for drug delivery applications

Supplementary files

Article information

Article type
Communication
Submitted
11 Oct 2004
Accepted
11 Jan 2005
First published
10 Feb 2005

Chem. Commun., 2005, 1830-1832

Fluorescent dendrimers with a peptide cathepsin B cleavage site for drug delivery applications

S. Fuchs, H. Otto, S. Jehle, P. Henklein and A. D. Schlüter, Chem. Commun., 2005, 1830 DOI: 10.1039/B415651J

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