Issue 14, 2005
From the journal:

Chemical Communications

Fluorescent dendrimers with a peptide cathepsin B cleavage site for drug delivery applications†

Sabine Fuchs,a   Henning Otto,*b   Stefan Jehle,ac   Peter Henkleinc  and  A. Dieter Schlüter*ad  

* Corresponding authors

a Freie Universität Berlin, Institut für Chemie/Organische Chemie, Takustr. 3, D-14195 Berlin, Germany

b Freie Universität Berlin, Institut für Chemie/Biochemie, Thielallee 63, D-14195 Berlin, Germany
E-mail: hotto@chemie.fu-berlin.de
Fax: +49 30 838 53753
Tel: +49 30 838 56425

c Medizinische Fakultät der Humboldt-Universität zu Berlin, Universitätsklinikum Charité, Monbijoustr. 2, 10098 Berlin, Germany
E-mail: peter.henklein@charite.de
Fax: +49 30 450528030
Tel: +49 30 450528904

d New, HCI J 541, CH-8093 Zürich, ETH Hönggerberg, Department of Materials, Switzerland
Fax: +41 1 6331395
Tel: +41 1 6336380

Abstract

The synthesis of a multifunctionally equipped first generation (G1) dendrimer carrying a pentapeptide with a cathepsin B cleavage site, chelating ligands for Pt2+-complexation, and a dansyl fluorescence marker is described and an investigation of its cellular uptake as well as intracellular localization by confocal fluorescence microscopy reported.

Graphical abstract: Fluorescent dendrimers with a peptide cathepsin B cleavage site for drug delivery applications

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Article information

DOI
https://doi.org/10.1039/B415651J
Article type
Communication
Submitted
11 Oct 2004
Accepted
11 Jan 2005
First published
10 Feb 2005

Chem. Commun., 2005, 1830-1832

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Fluorescent dendrimers with a peptide cathepsin B cleavage site for drug delivery applications

S. Fuchs, H. Otto, S. Jehle, P. Henklein and A. D. Schlüter, Chem. Commun., 2005, 1830 DOI: 10.1039/B415651J

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