Luminescent cyclometalated platinum(II) complexes with amino acid ligands for protein binding

Phyllis Kit-Man Siu; Dik-Lung Ma; Chi-Ming Che

doi:10.1039/B414936J

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Luminescent cyclometalated platinum(ii) complexes with amino acidligands for protein binding†

Phyllis Kit-Man Siu,^a Dik-Lung Ma^a and Chi-Ming Che*^a

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* Corresponding authors

^a Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong
E-mail: cmche@hku.hk
Fax: + 85 2 2857-1586

Abstract

Pt(C^N)(phe) (1, C^N = 2-(2′-thienyl)pyridine, phe = phenylalanine) shows a high binding affinity (ca. 10⁶ dm³ mol⁻¹) and selectivity towards human serum albumin (HSA) and such binding is accompanied by an enhancement of photoluminescence at 562 nm; both the protein binding affinity and cytotoxicities of [Pt(C^N)(phe) (1), Pt(C^N)(trp) (2, trp = tryptophan) and Pt(C^N)(gly) (3, gly = glycine)] are affected by the amino acid ligand with 1 having an IC₅₀ of up to 1 μM against a number of carcinoma cell lines.

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Supplementary files

Experimental details; synthesis and characterisation of complexes 1-3; restriction endonuclease fragmentation assay (Fig. S1); UV melting curve (Fig. S2); absorption titration spectra (Fig. S3); emission titration spectra (Figs. S4-S6); chromatogram (Fig. S7); flow cytometric analysis data (Fig. S8); emission intensity data (Table S1); native polyacrylamide gel electrophoresis data (Table S2) PDF (522K)

Article information

DOI: https://doi.org/10.1039/B414936J
Article type: Communication
Submitted: 28 Sep 2004
Accepted: 15 Nov 2004
First published: 05 Jan 2005

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Chem. Commun., 2005, 1025-1027

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Luminescent cyclometalated platinum(II) complexes with amino acid ligands for protein binding

P. Kit-Man Siu, D. Ma and C. Che, Chem. Commun., 2005, 1025 DOI: 10.1039/B414936J

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Chemical Communications

Luminescent cyclometalated platinum(ii) complexes with amino acidligands for protein binding†

Abstract

Supplementary files

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Luminescent cyclometalated platinum(II) complexes with amino acid ligands for protein binding

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