Issue 5, 2005
From the journal:

Chemical Communications

Calmodulin methionine residues are targets for one-electron oxidation by hydroxyl radicals: formation of S∴N three-electron bonded radical complexes

Thomas Nauser,a   Michael Jacoby,b   Willem H. Koppenol,a   Thomas C. Squierb  and  Christian Schöneichac  

a Laboratory of Inorganic Chemistry, ETH Zürich, Zürich, Switzerland

b Pacific Northwest National Laboratory, Richland, WA, USA

c Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS, USA
E-mail: schoneic@ku.edu
Fax: +1 (785) 864 5736
Tel: +1 (785) 864 4880

Abstract

The one-electron oxidation of calmodulin, studied on the microsecond timescale by pulse radiolysis, leads to methionine sulfide radical cations, which complex to adjacent amide groups to form three-electron bonded intermediates.

Graphical abstract: Calmodulin methionine residues are targets for one-electron oxidation by hydroxyl radicals: formation of S∴N three-electron bonded radical complexes

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Article information

DOI
https://doi.org/10.1039/B414687E
Article type
Communication
Submitted
23 Sep 2004
Accepted
25 Oct 2004
First published
10 Dec 2004

Chem. Commun., 2005, 587-589

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Calmodulin methionine residues are targets for one-electron oxidation by hydroxyl radicals: formation of S∴N three-electron bonded radical complexes

T. Nauser, M. Jacoby, W. H. Koppenol, T. C. Squier and C. Schöneich, Chem. Commun., 2005, 587 DOI: 10.1039/B414687E

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